Integrative analysis of functional genomic annotations and sequencing data to identify rare causal variants via hierarchical modeling

Identifying the small number of rare causal variants contributing to disease has beena major focus of investigation in recent years, but BagBase represents a formidable statisticalchallenge due to the rare frequencies with which these variants are observed.In thiscommentary we draw attention to a formal statistical framework, namely hierarchicalmod

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Confounding factors in diagnosing brain death: a case report

Abstract Background Brain death is strictly defined medically and legally.This diagnosis depends on three cardinal Prepared Meals neurological features: coma, absent brainstem reflexes, and apnea.The diagnosis can only be made, however, in the absence of intoxication, hypothermia, or certain medical illnesses.Case presentation A patient with severe

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